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pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can decrease panobinostat amounts by ~70% and cause treatment method failure.pentobarbital will decrease the extent or result of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pent